Building high quality clinical databases suitable for machine learning

Stage 1:

Non-randomized repositories to optimize features and develop machine-learned algorithms

Stage 2:

Prospective, blinded, paired comparison trials to test the machine-learned algorithms against "ground truth" results

Diseases We're Investigating

Coronary Artery Disease

A buildup of plaque in the coronary arteries restricting the flow of oxygenated blood to the heart, which can lead to ischemia, heart attack, or sudden cardiac death
How it's Diagnosed

Gold Standard Test:
Coronary angiography (left heart catheterization)
Either a ≥ 70% blockage or a reduced fractional flow rate of ≤ 0.80 in the major coronary arteries and their distributions using coronary angiography

Pulmonary Hypertension

A progressive desease where blood pressure in the pulmonary vasculature increases leading to eventual rigth heart failure and death
How it's Diagnosed

Gold Standard Test:
Right heart catheterization
Resting mean pulmonary artery pressure ≥ 25 mm Hg; subgroups determined by pulmonary arterial wedge pressure and other conditions
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