Coronary Artery Disease Facts

Coronary Artery Disease (CAD) involves the buildup of plaque within coronary arteries, which supply the heart with oxygen. This buildup restricts blood flow and can lead to ischemia, heart attack, or sudden cardiac death. Possible causes of CAD include hereditary factors, diet, and lifestyle choices (e.g., tobacco use, etc.).

CAD can be treated percutaneously (angioplasty/stenting), surgically (coronary artery bypass grafting), and/or pharmacologically (e.g., statins, etc.).

15.5 Million

People diagnosed in the U.S.1


Deaths in the U.S. per year2

$182 Billion

U.S. cost per year1

1American Heart Association, 2015 Heart Disease and Stroke Statistics Update.
2Centers for Disease Control and Prevention, Heart Disease Facts.

Current CAD Diagnostic Pathway

Diagnosing CAD currently involves leading the patient through an escalating pathway of tests, which may ultimately lead to the ‘gold standard’ for diagnosis – coronary angiography.

The exact sequence of testing can vary due to numerous factors but generally offers the benefit of clinical information at the expense of increased time, cost, and/or health risk. Currently, reaching a diagnosis and proceeding to treatment can take weeks.


Chest Pain

Chest pain is the most common symptom of CAD. However, several conditions can lead to chest pain.

with PCP

Physical Exam

Chest pain is first assessed by a physical exam and careful review of a patient’s history.

Examination with

Physical Exam

Chest pain is first assessed by a physical exam and careful review of a patient’s history.

ECG (or EKG)

Resting ECG (or EKG)

An electrocardiogram (ECG) records the electrical activity of the heart, typically with a 12-electrode setup. It’s typically the starting point in assessing several cardiac diseases and finding the cause of unexplained chest pain.

ECG Stress Test

Stress ECG (or EKG)

Using the same 12-electrode setup as a resting electrocardiogram (ECG), a patient may undergo a stress ECG to measure cardiac function when the heart rate is accelerated.

Stress Echo

Stress Echocardiography (Echo)

This ultrasound-based test reads sound waves and displays them as moving pictures of the heart on a video monitor. Two independent echo tests are performed – one at rest and a second after exercise to study the heart under stress. While this test does not image coronary arteries, it can be used to assess wall motion abnormalities that could indicate CAD.

Stress Test

Myocardial Perfusion Imaging (MPI)

This imaging procedure relies on radioactive isotopes injected into the bloodstream. These isotopes, visible to a special gamma camera, can be used to measure how well blood flows through the heart muscle. Like other stress tests, MPI involves an initial resting scan as well as a second, post-stress scan.


Computed Tomography Angiography (CTA)

This imaging procedure uses images generated by an x-ray machine and camera to identify narrowing or blockage of arteries. Patients are injected with a contrasting agent prior to the procedure.


Coronary Angiography (“Cardiac Catheterization”)

Coronary angiography is considered the “gold standard” definitive test for CAD. In this procedure, a catheter is inserted into the coronary arteries and dye is injected, which can be seen under x-ray fluoroscopy. This dye traces a detailed image of the vessels, which can be used to assess blockage. If the presence of significant CAD is detected, percutaneous coronary interventions (PCIs) can be performed during the procedure.

The First Medical Application of Phase Space Tomography™

CorVista® – our cardiac imaging solution – has the potential to transform diagnostic pathways. By leveraging machine learning with our Phase Space Tomographic (PST) images, we have developed a diagnostic test that utilizes only resting phase signals.

In a single visit, a patient can undergo a CorVista scan and meet with a physician. This encounter does not entail radiation, heart rate acceleration, or injections of contrast agents. And the physician will have the patient’s PST image available at their fingertips via our cloud-based, HIPAA-compliant web portal.

These results, in combination with a patient’s medical history, risk factors, and symptoms, could be used by the interpreting physician to recommend further treatment.

Caution—Investigational Device. Limited by Federal Law to Investigational Use. CorVista® is not available for commercial distribution.

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